MyBioSource.com's Mouse monoclonal TCF11/NRF1 antibody is a Human, and Mouse monoclonal antibody. The Mouse monoclonal TCF11/NRF1 antibody was generated using Lcrf1, NFE2L1, NRF1, nuclear respiratory factor 1, and TCF11 as the antigen. It reacts with Human. This antibody has been shown to work in applications such as: Western Blot.
Description
Transcription factor that activates the expression of the EIF2S1(EIF2-alpha)gene.Links the transcriptional modulation of key metabolic genes to cellular growth and development.Implicated in the control of nuclear genes required for respiration,heme biosynthesis,and mitochondrial DNA transcription and replication.
This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration,heme biosynthesis,and mitochondrial DNA transcription and replication.The protein has also been associated with the regulation of neurite outgrowth.Alternate transcriptional splice variants,which encode the same protein, have been characterized.Additional variants encoding different protein isoforms have been described but they have not been fully characterized.Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for ""nuclear factor(erythroid-derived 2)-like 1"" which has an official symbol of NFE2L1.[provided by RefSeq, Jul 2008]"